понедельник, 6 июня 2011 г.

Bone Marrow Microenvironment Can Contribute To Blood Cell Disorder

Disorders of blood cells may begin in the biological environment where the cells develop, not just with the cells themselves, according to a study from researchers at the Massachusetts General Hospital (MGH) and the Peter MacCallum Cancer Center (Peter Mac) in Melbourne, Australia. In Cell, the investigators describe finding that genetic alterations in the bone marrow of mice can cause a type of myeloproliferative syndrome, an overproduction of certain blood cells that also occurs in human patients.



"Previously all myeloproliferative syndromes have been considered to be intrinsic to the blood cells themselves," says Louise Purton, PhD, of the MGH Center for Regenerative Medicine, formerly of Peter Mac, who led the study. "This discovery may help us find better therapies for these disorders, which can be quite difficult to treat, and also for some leukemias."



How the bone marrow microenvironment contributes to the development and maintenance of blood cells has been the subject of intense research interest in recent years. In 2003 MGH researchers found that the bone-forming osteoblasts that line the marrow cavity can regulate the production of hematopoietic (blood system) stem cells. Although it is known that certain blood disorders can affect this microenvironment, the induction of a blood-cell disease by environmental factors alone has not been reported previously.



Purton's team has been studying how a group of vitamin A receptor molecules regulate hematopoietic stem cell (HSC) production and previously showed that the RAR-gamma receptor was critical to HSC renewal. In that work they observed that mice in which RAR-gamma had been knocked out had significantly fewer HSCs and increased numbers of more mature progenitor cells.



In the current study the investigators observed that mice in which RAR-gamma had been knocked out also had abnormal hematopoiesis of mature cells, with an overproduction of several types of white blood cells. In aged knockout mice, the condition was advanced and strongly resembled human myeloproliferative syndromes. When the RAR-gamma-negative knockout mice received transplants of bone marrow from normal mice, the disorder continued despite the presence of donor-derived RAR-gamma-positive hematopoietic cells in the marrow, indicating that the lack of RAR-gamma in the overall microenvironment was behind the disorder.



"There have been reports of patients with myeloproliferative syndromes receiving stem cell transplants and relapsing with an overproliferation of donor-based cells, despite no evidence of any disease in the donors," says Purton. "That indicates that what we observed in these knockout mice may be happening in these patients because their disease also is based in the microenvironment. Understanding how the microenvironment contributes to such diseases may lead us to better therapies. We also hope to examine whether the microenvironment may contribute to the transformation of abnormal noncancerous blood cells into leukemic cells." Purton is an instructor in Medicine at Harvard Medical School and also is associated with the Harvard Stem Cell Institute.

New FDA Approved Treatment For Head Lice Is Safe And Effective In Children As Young As 6 Months Old

A new non-neurotoxic treatment for head lice has been found to have an average of 91.2% treatment success rate after one week, and to be safe in humans from six months of age and up. This is the finding of a study published in Pediatric Dermatology.



Benzyl Alcohol Lotion 5% (known as UlesfiaTM) works by suffocating lice, a method which has been attempted by treating with household items such as mayonnaise, olive oil and petroleum jelly. Studies have shown that overnight treatments with these home remedies may initially appear to kill lice, but later a "resurrection effect" occurs after rinsing, because lice can resist asphyxiation. This is accomplished by the louse's ability to presumably close its spiracles, the external entry points to the breathing apparatus, when submerged. Unlike commonly used asphyxiant remedies, scanning electron microscopy appears to indicate that benzyl alcohol lotion effectively asphyxiates lice by "stunning" the spiracles open, allowing the lotion, comprised of mineral oil and other inactive ingredients, to infiltrate the "honeycomb" respiratory apparatus and kill lice.



The phase III trials were comprised of two multicenter, randomized, double-blind, placebo-controlled trials, conducted among ten geographically diverse sites which assessed the clinical effectiveness and safety of benzyl alcohol lotion. 250 participants took part in the trials and were randomised to treatment or vehicle (lotion but with no active ingredient) groups, treatment was given at day one and day seven, and participants were checked for success at day eight and day 14. On day eight the treatment group had a success rate of 91.2% as an average of both trials, and a 75.6% success rate on day 14; in the vehicle group the success rates were 27.9% and 15.5% respectively.



"Existing over-the-counter head lice treatments contain neurotoxic pesticides as active ingredients, resulting in potential toxicity and other problems, including lengthy applications, odor, ineffective treatment. Resistance has also become a problem now that lice have had such prolonged exposure to these products," said study author Terri L Meinking, PhD, of Global Health Associates of Miami, USA. "This leaves practitioners, parents and patients hoping for a safe, non-neurotoxic cure."



"Since the most popular products have been made readily available, their overuse has caused lice to become resistant just as bacteria have become resistant to many antibiotics," added Meinking. "Because benzyl alcohol lotion kills by suffocation, resistance should not be an issue."



Source:

Jennifer Beal

Wiley-Blackwell

Discovery To Aid Study Of Biological Structures, Molecules

Researchers in the United States and Spain have discovered that a tool widely used in nanoscale imaging works differently in watery environments, a step toward better using the instrument to study biological molecules and structures.



The researchers demonstrated their new understanding of how the instrument - the atomic force microscope - works in water to show detailed properties of a bacterial membrane and a virus called Phi29, said Arvind Raman, a Purdue professor of mechanical engineering.



"People using this kind of instrument to study biological structures need to know how it works in the natural watery environments of molecules and how to interpret images," he said.



An atomic force microscope uses a tiny vibrating probe to yield information about materials and surfaces on the scale of nanometers, or billionths of a meter. Because the instrument enables scientists to "see" objects far smaller than possible using light microscopes, it could be ideal for studying molecules, cell membranes and other biological structures.



The best way to study such structures is in their wet, natural environments. However, the researchers have now discovered that in some respects the vibrating probe's tip behaves the opposite in water as it does in air, said Purdue mechanical engineering doctoral student John Melcher.



Purdue researchers collaborated with scientists at three institutions in Madrid, Spain: Universidad AutГіnoma de Madrid, Instituto de Ciencia de Materiales de Madrid and the Centro Nacional de BiotecnologГ­a.



Findings, which were detailed in a paper appearing online last week in the U.S. publication Proceedings of the National Academy of Sciences, are related to the subtle differences in how the instrument's probe vibrates. The probe is caused to oscillate by a vibrating source at its base. However, the tip of the probe oscillates slightly out of synch with the oscillations at the base. This difference in oscillation is referred to as a "phase contrast," and the tip is said to be out of phase with the base.



Although these differences in phase contrast reveal information about the composition of the material being studied, data can't be properly interpreted unless researchers understand precisely how the phase changes in water as well as in air, Raman said.



If the instrument is operating in air, the tip's phase lags slightly when interacting with a viscous material and advances slightly when scanning over a hard surface. Now researchers have learned the tip operates in the opposite manner when used in water: it lags while passing over a hard object and advances when scanning the gelatinous surface of a biological membrane.



Researchers deposited the membrane and viruses on a sheet of mica. Tests showed the differing properties of the inner and outer sides of the membrane and details about the latticelike protein structure of the membrane. Findings also showed the different properties of the balloonlike head, stiff collar and hollow tail of the Phi29 virus, called a bacteriophage because it infects bacteria.



"The findings suggest that phase contrast in liquids can be used to reveal rapidly the intrinsic variations in local stiffness with molecular resolution, for example, by showing that the head and the collar of an individual virus particle have different stiffness," Raman said.



Notes:

The research was funded by the National Science Foundation and was conducted at the Birck Nanotechnology Center in Purdue's Discovery Park. The biological membrane images were taken at Purdue, and the virus studies were performed at the Universidad AutГіnoma de Madrid. The paper was authored by Melcher; Carolina Carrasco, a postdoctoral researcher at Universidad AutГіnoma de Madrid and the Instituto de Ciencia de Materiales de Madrid; Purdue postdoctoral researcher Xin Xu; JosГ© L. Carrasco, a researcher at Departmento de Estructura de MacomolГ©culas, Centro Nacional de BiotecnologГ­a, Consejo Superior de Investigaciones CientГ­ficas; Julio GГіmez-Herrero and Pedro JosГ© de Pablo, both researchers from Universidad AutГіnoma de Madrid; and Raman.



Source:
Emil Venere


Purdue University

Most valuable prize in German research goes to ten scientists & academics

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) Grants Committee today named the prizewinners of
the DFG's Gottfried Wilhelm Leibniz Programme for 2005. The most valuable research prize in Germany will go to ten scientists
and academics, two women and eight men. The prize of 1.55 million euros funds research work over a five-year period and can
be used flexibly by the prizewinners, depending on their specific requirements.


The programme, established in 1985, aims to improve the working conditions of outstanding researchers, to extend their
research opportunities, to relieve them of administrative work and make it easier for them to employ especially highly
qualified young researchers. Scientists and academics from all research areas can be nominated for the award. The DFG
Nominations Committee considers the nominations it receives for the Gottfried Wilhelm Leibniz Prize and selects researchers
who, above all, can be expected to particularly advance their scientific achievement with this additional boost in funding.
This year's prizewinners again include a number of younger scientists.


Today's decision brings the total number of prizes awarded under the Leibniz Programme to 228. Of these, 49 winners have been
from the humanities, 64 from the life sciences, 81 from the natural sciences and 34 from engineering. Of 130 nominations
received for 2005, the following ten Leibniz Prizewinners were selected:


Prof. Dr. Peter B. Becker (46), Cell Biology/Biochemistry, University of Munich (1.55 million euros)


The biochemist Peter Becker studies chromatin dynamics, in other words, the packaging of DNA. The human genetic code is
contained in long DNA sequences. In order to fit inside a cell, these sequences have to be "packed". The degree of packing is
also determined by the degree to which a DNA sequence is utilised. This complex organisational structure of DNA is called
chromatin. Peter Becker is looking into the question of how the packaging of the DNA relates to the control of gene activity.
Through his research, he has been able to discover a new principle of chromatin dynamics. Amongst other things, he has shown
that the histones - proteins which act as a kind of spool for the DNA - are pushed along the DNA sequence if they get "in the
way" of the activation of certain sections of the DNA. These findings are of great importance for understanding gene activity
relating to the development of cancer and embryo growth.


Peter Becker studied biology in Heidelberg and obtained his doctorate in biochemistry. After spending three years as a
post-doc at the National Institutes of Health (NIH) in the USA he led a group at the European Molecular Biology Laboratory
(EMBL) in Heidelberg from 1991 until 1999. Since 1999 he has held the chair for molecular biology at the Adolf Butenandt
Institute at the Ludwig Maximilians University of Munich.















Prof. Dr. Immanuel F. Bloch (32), Experimental Physics, University of Mainz (1.55 million euros)


Immanuel Bloch achieved his first scientific breakthrough in 1999 with his development of the "Munich Atom Laser" together
with other researchers. This experiment was the first to produce a continuous matter wave beam from Bose-Einstein
condensates. These waves are similar to the beam of light emitted by a laser, but unlike a laser beam, consist of ultracold
atoms. By superposing two such matter waves it is possible to obtain an interference pattern of alternating constructive and
destructive interference of the matter waves in the same way as with conventional lasers. Another area which Immanuel Bloch's
research focuses on is the manipulation of ultracold Bose gases using an optical lattice. Using laser beams he was, for the
first time, able to alter a Bose-Einstein condensate to bring about a phase transition to a state called the Mott isolator.
This state of matter has fundamental new properties, which can be utilised for applications such as the development of
quantum computers.


Immanuel Bloch studied physics at the University of Bonn from 1991 until 1996. Following a one year research visit to
Stanford University in the USA from 1997-98 he obtained his doctorate in Munich in 2000. In 2003, at just 31 years of age, he
was appointed to a professorship at the University of Mainz.


Prof. Dr. Stefanie Dimmeler (37), Molecular Cardiology, University of Frankfurt/Main (1.55 million euros)


Stefanie Dimmeler's field of research is the biology of the blood vessels. She hopes to create the foundation for new methods
of treatment for cardiovascular diseases through improved understanding of the biological and pathological processes in the
vessel wall. The main topic of her research is programmed cell death (apoptosis) in the blood vessel wall, called the
endothelium. Every cell carries in its DNA a kind of self-destruct mechanism, which is set off in response to certain signals
and which is necessary for the regeneration of tissue and for growth. This stop code is usually set off by chemical
messengers, but can also be triggered by damage caused to the cells. Stefanie Dimmeler has studied the fundamental processes
of vascular cell damage and regeneration, thus contributing significantly to the understanding of arteriosclerosis
(thickening and hardening of the arterial walls). Furthermore, her work on the bone marrow-derived precursor cells
(progenitor cells) of blood vessels formed the basis for the first clinical studies of stem cell therapy of heart attack
patients.


Stefanie Dimmeler studied biology in Constance and obtained her doctorate in 1993. She went to the University of Frankfurt in
1995, where she has been the director of molecular cardiology since 1997. She qualified as a professor in 1998 and was
appointed as professor of molecular cardiology at the University of Frankfurt in 2000.


Prof. Dr. Jьrgen GauЯ (44), Physical Chemistry/Theoretical Chemistry, University of Munich (1.55 million euros)



Jьrgen GauЯ is working on theoretical quantum chemistry. This is an area of increasing importance in chemical research.
Experimental studies are increasingly being combined with quantum chemical calculations in order to confirm experimental
data, to simplify the evaluation of the data or indeed enable evaluation, or to gain new insights. Jьrgen GauЯ has made
fundamental contributions to the methodology in this area as well as putting the theory into practice in high-performance
computer programmes that are already being used by a large number of research groups around the world. His work has been
recognised with many national and international prizes, including the famous prize of the Berlin-Brandenburg Academy of
Sciences and the International Academy of Quantum Molecular Science medal.


Jьrgen GauЯ studied chemistry in Cologne and obtained his doctorate there in 1988 with his thesis on theoretical chemistry.
As a postdoctorate researcher he first went to the University of Washington in Seattle, USA, and was subsequently involved in
the Quantum Theory Project at the University of Florida in Gainesville. In 1993 he qualified as a professor at the University
of Karlsruhe and was appointed as a professor at the University of Mainz in 1995. He has held the newly established chair for
theoretical chemistry there since 2001.


Prof. Dr. Gьnther G. Hasinger (50), Astrophysics, Max Planck Institute for Extraterrestrial Physics, Garching (1.55
million euros)


Gьnther Hasinger is one of the world's leading researchers in the field of X-ray astronomy. In 2002 he and his team became
the first to prove the impending merger of two supermassive black holes in a distant galaxy. For the past few years Gьnther
Hasinger has been working on studying the X-ray background. His research has helped to prove that this diffuse faint glow of
X-rays comes essentially from many individual celestial objects. His research on the formation of galaxies has contributed
decisively to massive black holes in the centre of galaxies being regarded as the seeds for their formation, rather than the
product of their development. Gьnther Hasinger is currently involved in studying the cores of active galaxies as well as
being involved in the hunt for dark matter. As part of this work he is actively involved in the development of X-ray
telescope satellites, which it is hoped will provide answers to various questions on the distribution of matter and the early
development of stars and galaxies.


Gьnther Hasinger studied physics at the Ludwig Maximilians University of Munich and completed his doctorate in astronomy
there in 1984. Following his qualification as a professor in 1995 he was first appointed as a professor at the University of
Potsdam, where he was also director of the Astrophysical Institute. Since 2001 he has been the director of the Max Planck
Institute for Extraterrestrial Physics in Garching.


Prof. Dr. Christian Jung (48), Molecular Plant Breeding, University of Kiel (1.55 million euros)


Christian Jung has been researching the breeding of agriculturally cultivated crop plants for many years. For his work he
uses molecular plant genetics, which enables the breeding of plants that are resistant to pathogens through carefully
directed genetic manipulation. He successfully determined a resistance gene to protect sugar beet from threadworms
(nematodes). The gene, which was originally isolated from a wild form of sugar beet, makes cultivated varieties fully
resistant to the nematodes, one of the major pests in sugar beet. Christian Jung has also had great success in isolating
genes which determine the sexual differentiation of plants. This work is of great importance, not only for basic molecular
research, but also for plant breeding as a whole. Through his many years of involvement in the Central Commission for
Biosafety (Zentrale Kommission fьr die Biologische Sicherheit) and public statements on the amendment of the Genetic
Engineering Law Christian Jung has also made an important scientific contribution to the objectification of the debate on
environmentally friendly genetic engineering.


Christian Jung studied agricultural sciences in Gцttingen and worked at the University of Munich after obtaining his
doctorate, where he qualified as a professor in 1992 with his thesis on the molecular genome analysis of crops. In 1993 he
became the director of the Institute of Crop Science and Plant Breeding at the University of Kiel.


Prof. Dr. Axel Ockenfels (35), Experimental Economics, University of Cologne (1.55 million euros)


Axel Ockenfels' research deals with peoples' behaviour when making economic decisions, or, to be more precise, what strategic
and rational factors affect these decisions. Using game theory Axel Ockenfels has developed a behavioural model that can be
used to both explain and predict apparently contradictory economic decision-making patterns. Online auction sites and markets
are a focal point of his research. He uses novel experimental techniques to analyse the strategic bidding behaviour and the
auction rules of Internet platforms and has in this way made highly complex real-life markets accessible to scientifically
sound investigation. His most recent work has dealt with market architecture, promising not only great potential for basic
research but also for the organisation of modern markets. Axel Ockenfels has published several groundbreaking papers in
leading international economic journals and is currently one of the most frequently cited authors of his field of research.



Axel Ockenfels obtained his doctorate in economics from the University of Magdeburg in 1998 and qualified as a professor
three years thereafter. In 2001 he became the leader of an independent junior research group in the DFG's Emmy Noether
Programme. From 2002 until 2003 he led a research group at the Max Planck Institute for Research into Economic Systems in
Jena. He has been a professor of economics and director of the Institute of Energy Economics and the Bonn Laboratory for
Experimental Economics since 2003.


Prof. Dr.-Ing. Wolfgang Peukert (46), Mechanical Process Engineering, University of Erlangen-Nuremberg (1.55 million
euros)


The success of research in engineering is partly measured by its potential for practical application. Researchers attempt to
understand the basic physical and chemical concepts of the interactions between particles and to use these with the aim of
obtaining particular product characteristics. Wolfgang Peukert has shown considerable success at this interface between basic
research and application. One of the focal points of his work is particle properties in the sub-micron size range. The
behaviour of and interaction between particles are decisive for the characteristics of a product. Whereas in the past the
particles of interest were larger than a micron, an increasing number of modern applications demand much smaller particles.
With his research into the properties of particles in the sub-micron and nanometre size range Wolfgang Peukert has shed light
on the scientific relationships and created the basis for the tailor-made design of product properties, and thus for
application.


After studying chemical engineering at the University of Karlsruhe and subsequently obtaining his doctorate in mechanical
process engineering, Wolfgang Peukert joined the R&D department of Hosokawa Micron and worked in Germany and Japan. In 1998
he accepted an appointment to the chair for Particle Technology at the Technical University of Munich and in early 2003 moved
to the Institute of Particle Technology at the University of Erlangen-Nuremberg.


Prof. Dr. Barbara Stollberg-Rilinger (49), Early Modern History, University of Mьnster (1.55 million euros)


Barbara Stollberg-Rilinger's particular interest lies in the political and cultural movements in Europe in the 17th and 18th
centuries. Besides the major philosophical and constitutional developments, such as the renaissance, she is also interested
in the developments in social and communication history, including religious revival movements and new forms of social and
family interaction. Her research is currently concentrated on the question of how the social order of ranks and classes in
the early modern era were constituted through symbolic acts, for instance rituals and ceremonies. Barbara Stollberg-Rilinger
always establishes links to the modern era in her work, and attempts to identify the relationship between developments in the
early modern era and issues pertaining to modernity. Many of her historical interests and methodological approaches also
contribute to the Collaborative Research Centre "Symbolic Communication and Social Value Systems from the Middle Ages to the
French Revolution" in Mьnster, of which she is the spokesperson.


Barbara Stollberg-Rilinger studied early modern and modern European history in Cologne and completed her doctorate in 1985
with her thesis on political metaphor in the absolute sovereign state. She qualified as a professor in 1994 and was appointed
as a university lecturer at the University of Cologne in 1996. She has held the chair for modern history with a particular
emphasis on early modern history at the university of Mьnster since 1997.


Prof. Dr. Andreas Tьnnermann (41), Micro System Technology, University of Jena, Fraunhofer Institute for Applied Optics
and Precision Engineering, Jena (1.55 million euros)


Andreas Tьnnermann has published groundbreaking research on the development of high power fibre lasers, thus laying the
foundation for the production of simple, compact and robust lasers with high beam quality. The low efficiency of conventional
fibre lasers in the past restricted them to use for amplification in communications networks. It was not until the work done
by Andreas Tьnnermann that it became possible to build fibre lasers with both a consistently high power emission signal as
well as ultra short pulses with high beam quality. He also accomplished decisive pioneering work on the improvement of the
optical properties of optical fibres for light emission and thus of their usefulness for lasers. For the first time this
makes high efficiency laser sources that can be used as components in integrated optics available. The work of Andreas
Tьnnermann has opened up new possibilities for the use of modern laser fibres, ranging from basic research and the
development of new materials through to biophotonics.


After completing his doctorate in laser physics at the University of Hannover Andreas Tьnnermann became head of the
department of development at the Laser Zentrum Hannover in 1992. He qualified as a professor of experimental physics in 1997
and was appointed as a professor of applied physics at the University of Jena in 1998, at the age of 34, where he has since
been the director of the Institute of Applied Physics. Simultaneously he is also the director of the Fraunhofer Institute for
Applied Optics and Precision Engineering.


The award ceremony for the Gottfried Wilhelm Leibniz Programme 2005 will take place on 2 March 2005 at the Berlin-Brandenburg
Academy of Science in Berlin. The prizes will be awarded by the President of the DFG, Professor Ernst-Ludwig Winnacker.



Note to editors: Further information on the prizewinners for 2005, including their CVs, details of their key research areas
and photographs will be available at dfg as from 20 January. General information on the Gottfried Wilhelm Leibniz
Programme can also be found at this address.


This release is also available in German


Contact: Cornelia Pretzer

Leibniz prizewinners 2005

cornelia.pretzerdfg

49-228-885-2376

Deutsche Forschungsgemeinschaft

Linking Players In Blood Pressure Control To Metabolic Syndrome

A new study elucidates the connection between an enzyme involved in blood pressure control and symptoms of the metabolic syndrome. The researchers report in the December issue of Cell Metabolism, a publication of Cell Press, that mice lacking the enzyme known as renin are lean and resistant to gaining weight on a high-fat diet, even though they continue to eat just as much and don't exercise more.



The findings suggest that renin-blocking drugs designed for treating high blood pressure might also improve obesity and insulin resistance, according to the researchers. Renin plays an important rate-limiting role in the production of a hormone called angiotensin II (Ang II) that increases blood pressure by constricting blood vessels.



"An overactive renin-angiotensin system has also been associated with obesity and the metabolic syndrome," said Nobuyuki Takahashi of The University of North Carolina at Chapel Hill. "Now we've gained new insight into the mechanism responsible."



The metabolic syndrome is characterized by central obesity, hypertension, abnormally high blood lipid levels, and impaired glucose tolerance, the researchers explained. It also increases the risk of heart disease and type 2 diabetes. While most theories to explain the condition have focused on primary defects of insulin action, the renin-angiotensin system has also been implicated.



Clinical trials have shown that drugs that block other parts of the renin-angiotensin system improve insulin sensitivity and decrease the incidence of type 2 diabetes. Studies have also revealed that mice lacking angiotensinogen, the substrate that renin acts on, are lean and resistant to diet-induced obesity.



In the current study, the researchers generated mice with a predisposition for obesity that were also deficient for renin. They found that the renin-less mice were lean, resistant to diet-induced obesity, and more insulin sensitive than normal mice.



"This metabolically favorable state results partly from an increased metabolic rate and partly from gastrointestinal loss of dietary fat, but not from increased physical activity or decreased food intake," they said. The metabolic effects were explained almost entirely by a lack of Ang II in the absence of renin. Renin's other effects on metabolism were minimal.



"Our findings are particularly relevant since they suggest that renin inhibitors recently approved or under development for the treatment of hypertension are likely to have favorable effects on obesity, insulin sensitivity, and their associated metabolic and cardiovascular consequences," the researchers said.







The researchers include Nobuyuki Takahashi, Feng Li, Kunjie Hua, Jianbei Deng, Chih-Hong Wang, Hyung-Suk Kim, and Joyce B. Harp, of The University of North Carolina at Chapel Hill, in Chapel Hill, NC, USA; Robert R. Bowers, and Timothy J. Bartness, of the Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA.



Source:

Cathleen Genova

Cell Press

Howard J. Federoff, M.D., Ph.D. Of Georgetown University Presented With Bernard Sanberg Memorial Award

The American Society for Neural Therapy and Repair (ASNTR), which held its 16th Annual Meeting April 30 - May 2 in Clearwater Beach, Florida, has awarded The 2009 Bernard Sanberg Memorial Award for Brain Repair to Howard J. Federoff, MD, PhD, Executive Vice President for Health Services and Executive Dean of the School of Medicine at Georgetown University.



The Award is named for Bernard Sanberg, father of Dr. Paul Sanberg, (University of South Florida), a co-founder of the ASNTR. After Bernard Sanberg died of a stroke in 1999, the award bearing his name was established and is given by the ASNTR annually to an individual who has made outstanding research contributions in the field of neural therapy and repair. The award is presented every year at ASNTR's Annual Meeting. The first Bernard Sanberg Memorial Award was given in 2000.



"The annual award is based on the quality of a researcher's contribution and its impact in advancing neural repair," said John Sladek, PhD, professor of pediatrics and neuroscience at the University of Colorado School of Medicine and ASNTR founding president.



Recent past winners include Paul Carvey, PhD, Rush University Medical Center (2008); Barry Hoffer, MD, PhD, NIDA/NIH (2007); and John Sladek, PhD, University of Colorado (2006).



Dr. Federoff is responsible for overseeing biomedical research at Georgetown University as well as advancing the educational and clinical missions of the university. His research interests include gene therapy and neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. He also holds a number of medical patents.



Prior to coming to Georgetown University, Dr. Federoff was Senior Associate Dean for Basic Research, Professor of Oncology and Genetics and Professor of Neurology, Medicine Microbiology and Immunology at the University of Rochester School of Medicine. He was the founding director of the Center for Aging and Development Biology at the Aab Institution of Biomedical Sciences at Rochester.



Source:
Donna Morrison


Cell Transplantation Center of Excellence for Aging and Brain Repair

Nanotubes Used For First Time To Send Signals To Nerve Cells

Texas scientists have added one more trick to the amazing repertoire of carbon nanotubes -- the ability to carry electrical signals to nerve cells.



Nanotubes, tiny hollow carbon filaments about one ten-thousandth the diameter of a human hair, are already famed as one of the most versatile materials ever discovered. A hundred times as strong as steel and one-sixth as dense, able to conduct electricity better than copper or to substitute for silicon in semiconductor chips, carbon nanotubes have been proposed as the basis for everything from elevator cables that could lift payloads into Earth orbit to computers smaller than human cells.



Thin films of carbon nanotubes deposited on transparent plastic can also serve as a surface on which cells can grow. And as researchers at the University of Texas Medical Branch at Galveston (UTMB) and Rice University suggest in a paper published in the May issue of the Journal of Nanoscience and Nanotechnology, these nanotube films could potentially serve as an electrical interface between living tissue and prosthetic devices or biomedical instruments.



"As far as I know, we're the first group to show that you can have some kind of electrical communication between these two things, by stimulating cells through our transparent conductive layer," said Todd Pappas, director of sensory and molecular neuroengineering at UTMB's Center for Biomedical Engineering and one of the study's senior authors. Pappas and UTMB research associate Anton Liopo collaborated on the work with James Tour, director of the Carbon Nanotechnology Laboratory at Rice's Richard E. Smalley Institute for Nanoscale Science and Technology, Rice postdoctoral fellow Michael Stewart and Rice graduate student Jared Hudson.



The group employed two different types of cells in their experiments, neuroblastoma cells commonly used in test-tube experiments and neurons cultured from experimental rats. Both cell types were placed on ten-layer-thick "mats" of single-walled carbon nanotubes (SWNTs) deposited on transparent plastic. This enabled the researchers to use a microscope to position a tiny electrode next to individual cells and record their responses to electrical pulses transmitted through the SWNTs.



In addition to their electrical stimulation experiments, the scientists also studied how different kinds of SWNTs affected the growth and development of neuroblastoma cells. They compared cells placed on mats made of "functionalized" SWNTs, carbon nanotubes with additional molecules attached to their surfaces that may be used to guide cell growth or customize nanotube electrical properties, to cells cultured on unmodified "native" carbon nanotubes and conventional tissue culture plastic.



"Native carbon nanotubes support neuron attachment and growth well -- as we expected, better than the two types of functionalized nanotubes we tested," Pappas said. "Next we want to find a way to functionalize the nanotubes to make neuron attachment and communication better and make these surfaces more biocompatible."



Another avenue Pappas wants to explore is finding out whether nanotubes are sensitive enough to record ongoing electrical activity in cells. "Where we want to get to is a device that can both sense and deliver stimuli to cells for things like prosthetic control," Pappas said. "I think it's definitely doable, and we're pursuing that with Jim Tour and his group. It's great to be able to work with a guy who's on the cutting edge of nanoelectronics technology -- he seems to develop something new every week, and it's really become a great interaction."







The University of Texas Medical Branch at Galveston

Public Affairs Office

301 University Boulevard, Suite 3.102

Galveston, Texas

utmb/



Contact: Jim Kelly

University of Texas Medical Branch at Galveston